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This reference features the latest findings surrounding the physicochemical aspects of surfactant
and polymer systems to facilitate the design and understanding of novel and advanced drug
delivery formulations. It highlights the basics of surfactant and polymer surface activity and self-assembly,
the various types of structures formed by such compounds, and how they may be used in drug delivery.
Surfactants and Polymers in Drug
Delivery discusses solubilization of drugs in micellar systems;
liquid crystalline phases formed by PEO—PPO—PEO block copolymers and other copolymers and
surfactants; triggered drug release from liposome formulations; microemulsions formed by ionic and
nonionic surfactants; microemulsions in oral and topical administration; emulsions in parental, oral, and
dermal drug delivery; gels formed by polysaccharides, block copolymers, and polymer—surfactant
mixtures; chemically cross-linked gels; and much more.
From the Preface: “Surfactant and polymer systems play an important role in modern drug
delivery, where they may allow control of the drug release rate, enhance effective drug solubility, minimize
drug degradation, contribute to reduced toxicity, and facilitate control of drug uptake. In all, they
contribute significantly to therapeutic efficiency. However, although understanding of the
physicochemical properties and behavior of surfactants and polymers in solution and at interfaces has
undergone dramatic development in the past couple of decades, the new findings have generally not been
fully implemented in drug delivery...”
Target Audience: Surface, pharmaceutical, colloid, polymer, and medicinal chemists; chemical,
formulation, and application engineers; pharmacists; and upper-level students of these disciplines.
Table of Contents:
Introduction
Micelles
Liquid Crystalline Phases
Liposomes
Microemulsions
Emulsions
Aerosols, Bubbles, and Foams
Polymer Solutions and Gels
Polymer Particles
Degradation of Surfactants and Polymers in Drug Delivery
Drying of Formulations Containing Surfactants and Polymers
Index
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