A Practical Guide to Chemical Safety Testing describes the different tests that must be performed on new chemicals and other materials to demonstrate to regulatory authorities that they are safe for use. Tests vary from physico-chemical, measuring properties such as melting point and density, through genetic toxicity studies, to mammalian toxicology and studies to investigate effects on the environment. Each test type is described here and the validity of the test methods is debated. The book clearly describes the process of obtaining approval for use in a variety of global regions.

From the Preface: “This [book] covers the basis of toxicology in relation to the safety assessment and regulatory requirements for chemicals, plastics, and rubber. It is aimed at manufacturers, distributors and users and hence covers industrial and household chemicals, food packaging, and medical devices. The emphasis is on providing a basis of understanding of toxicology, ecotoxicology and physico-chemical properties for hazard assessment and interpretation within risk assessment and regulatory frameworks...”

Target Audience: Manufacturers of chemicals, plastics, rubber, food packaging, medical devices, and related goods.

Table of Contents:

Introduction

Safety Testing and Assessment:

Mammalian Toxicology

Genetic Toxicology

Ecotoxicology

Physico-Chemical Properties

Alternatives to Animal Testing for Safety Evaluation

Toxicological Assessment within a Risk Assessment Framework

Environmental Risk Assessment

Regulatory Framework:

Chemical Legislation

Chemical Control in Japan

Chemical Control in the U.S. and the Rest of the World

Notification of Polymers Worldwide

Medical Device Regulation

Regulation of Food Packaging in the EU and US

Regulation of Biocides

Abbreviations and Acronyms

Index