This handbook offers an indispensable source of high quality information on the synthesis, reactivity, and applications of fluorine compounds. Much of the book is devoted to presenting a wide range of synthetic methodologies. The experimental procedures selected demonstrate that this can often be accomplished with standard laboratory equipment. There are also discussions of fluorous chemistry and the applications of organofluorine compounds in liquid crystals, polymers, pharmaceuticals, electronics, and more.

From the Preface: “...This book is aimed at the synthetic chemist who wants to gain a deeper understanding of the fascinating implications of including the highly unusual element fluorine in organic compounds. The idea behind this book was to introduce the reader to a wide range of synthetic methodology, based on the mechanistic background and the unique chemical and physicochemical properties of fluoroorganic compounds. There are quite some barriers to entering the field of preparative fluoroorganic chemistry, many based on unfounded prejudice. To reduce the threshold to practical engagement in fluoroorganic chemistry, I include some representative synthetic procedures which can be performed with relatively standard laboratory equipment...”

Target Audience: Organic, synthetic, and industrial chemists with an interest in fluoroorganic compounds; also research libraries and upper-level students in the field.

Table of Contents:

Introduction

Synthesis of Complex Organofluorine Compounds:

Introduction of Fluorine

Perfluoroalkynation

Selected Fluorinated Structures and Reaction Types

The Chemistry of Highly Fluorinated Olefins

Fluorine Chemistry:

Fluorous Biphase Catalysts

Fluorous Synthesis and Combinatorial Chemistry

Applications of Organofluorine Compounds:

Halofluorocarbons, Hydrofluorocarbons and Related Compounds

Polymers and Lubricants

Applications in Electronics Industry

Liquid Crystals for Active Matrix Liquid Crystal Displays

Pharmaceuticals and Other Biomedical Applications

Agricultural Chemistry

Appendix I: Typical Synthetic Procedures

Appendix II: Index of Synthetic Conversions

Index